Abstract
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
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CITATION STYLE
Zhou, W., Almeqdadi, M., Xifaras, M. E., Riddell, I. A., Yilmaz, Ö. H., & Lippard, S. J. (2018). The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex: Trans -[Pt(NH3)2(phenanthridine)Cl]NO3. Chemical Communications, 54(22), 2788–2791. https://doi.org/10.1039/c8cc00393a
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