Highly stereoselective one-pot synthesis of bicyclic isoxazolidines with five stereogenic centers by an organocatalytic process

Abstract

High five! A novel, facile, and highly stereoselective synthesis of the title compounds has been developed with the control of five stereogenic centers through an organocatalytic asymmetric one-pot tandem process involving a diastereoselective intramolecular nitrone [3+2] cycloaddition (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.