Xanthanolides with antitumour activity from Xanthium italicum

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Abstract

Bioassay-guided fractionation of a CHCl3 extract of the leaves of Xanthium italicum Moretti led to the isolation of four xanthanolides: xanthatin (1), 4-epixanthanol (2), 4-epi-isoxanthanol (3), and 2-hydroxyxanthinosin (4). Their structures were determined by means of 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, which resulted in complete and unambiguous 1H and 13C NMR chemical shift assignments. The isolated compounds 1-4 were evaluated for their antiproliferative activities, and were demonstrated to exert significant cell growth inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431), and breast adenocarcinoma (MCF7) cells. © 2009 Verlag der Zeitschrift für Naturforschung, Tübingen.

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APA

Kovács, A., Vasas, A., Forgo, P., Réthy, B., Zupkó, I., & Hohmann, J. (2009). Xanthanolides with antitumour activity from Xanthium italicum. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 64(5–6), 343–349. https://doi.org/10.1515/znc-2009-5-607

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