Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis

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Abstract

We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic. © 2007 Pharmaceutical Society of Japan.

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Horiuchi, K., Shiota, S., Kuroda, T., Hatano, T., Yoshida, T., & Tsuchiya, T. (2007). Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. Biological and Pharmaceutical Bulletin, 30(2), 287–290. https://doi.org/10.1248/bpb.30.287

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