Three experiments were conducted to evaluate the accuracy of urine ultraviolet fluorescent tests for riboflavin, which has been used as a tracer for medication compliance in several clinical drug trials. Observer accuracy in discriminating riboflavin-positive or negative urine samples was found to vary with the method of observation, dose of riboflavin, observer experience, and time postingestion. The results showed that, while the 5-mg dose used in previous clinical trials was too small to permit reliable assessment of compliance, larger doses of riboflavin could produce nearly 100% accuracy for minimally trained observers who used a matching-to-sample observation procedure. The findings are discussed in terms of the potential clinical and research applications of this type of simple but reliable compliance assessment procedure. © 1985 Plenum Publishing Corporation.
CITATION STYLE
Dubbert, P. M., King, A., Rapp, S. R., Brief, D., Martin, J. E., & Lake, M. (1985). Riboflavin as a tracer of medication compliance. Journal of Behavioral Medicine, 8(3), 287–299. https://doi.org/10.1007/BF00870315
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