Alloreactive T Cell Responses and Acute Rejection of Single Class II MHC-Disparate Heart Allografts Are under Strict Regulation by CD4+CD25+ T Cells

  • Schenk S
  • Kish D
  • He C
  • et al.
78Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Skin but not vascularized cardiac allografts from B6.H-2bm12 mice are acutely rejected by C57BL/6 recipients in response to the single class II MHC disparity. The underlying mechanisms preventing acute rejection of B6.H-2bm12 heart allografts by C57BL/6 recipients were investigated. B6.H-2bm12 heart allografts induced low levels of alloreactive effector T cell priming in C57BL/6 recipients, and this priming was accompanied by low-level cellular infiltration into the allograft that quickly resolved. Recipients with long-term-surviving heart allografts were unable to reject B6.H-2bm12 skin allografts, suggesting potential down-regulatory mechanisms induced by the cardiac allografts. Depletion of CD25+ cells from C57BL/6 recipients resulted in 15-fold increases in alloreactive T cell priming and in acute rejection of B6.H-2bm12 heart grafts. Similarly, reconstitution of B6.Rag−/− recipients with wild-type C57BL/6 splenocytes resulted in acute rejection of B6.H-2bm12 heart grafts only if CD25+ cells were depleted. These results indicate that acute rejection of single class II MHC-disparate B6.H-2bm12 heart allografts by C57BL/6 recipients is inhibited by the emergence of CD25+ regulatory cells that restrict the clonal expansion of alloreactive T cells.

References Powered by Scopus

Immunologic self-tolerance maintained by CD25<sup>+</sup>CD4<sup>+</sup> regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

1921Citations
N/AReaders
Get full text

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25<sup>+</sup>CD4<sup>+</sup> regulatory cells that control intestinal inflammation

1919Citations
N/AReaders
Get full text

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

959Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts

567Citations
N/AReaders
Get full text

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis

267Citations
N/AReaders
Get full text

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27<sup>+</sup> subset of human CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells

228Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Schenk, S., Kish, D. D., He, C., El-Sawy, T., Chiffoleau, E., Chen, C., … Fairchild, R. L. (2005). Alloreactive T Cell Responses and Acute Rejection of Single Class II MHC-Disparate Heart Allografts Are under Strict Regulation by CD4+CD25+ T Cells. The Journal of Immunology, 174(6), 3741–3748. https://doi.org/10.4049/jimmunol.174.6.3741

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 20

71%

Professor / Associate Prof. 4

14%

Researcher 4

14%

Readers' Discipline

Tooltip

Medicine and Dentistry 19

70%

Agricultural and Biological Sciences 3

11%

Biochemistry, Genetics and Molecular Bi... 3

11%

Immunology and Microbiology 2

7%

Save time finding and organizing research with Mendeley

Sign up for free