Although the presence of norepinephrine (NE) in the mammalian cerebellum was initially controversial, there is now substantial evidence of a role for the NE system in modulating the response properties of individual cerebellar neurons to synaptic inputs rather than transmitting moment-to-moment details of modality specific information. As a result of these cellular actions, the system is capable of regulating cerebellar circuit functions within the context of ongoing voluntary and reflex motor activities and in a manner appropriate to the behavioral state of the organism. The evidence for this mode of operation derives from extensive anatomical, physiological, and pharmacological investigations over a period of more than 40 years. This chapter summarizes those studies and the development of this concept.
CITATION STYLE
Chandler, D. J., Nicholson, S. E., Zitnik, G., & Waterhouse, B. D. (2013). Norepinephrine and synaptic transmission in the cerebellum. In Handbook of the Cerebellum and Cerebellar Disorders (pp. 895–914). Springer Netherlands. https://doi.org/10.1007/978-94-007-1333-8_37
Mendeley helps you to discover research relevant for your work.