Vascular responses in rodent models of traumatic brain injury

Abstract

The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant barriers to finding effective therapeutic interventions. Among multiple confirmed pathological events after TBI, vascular response or cerebrovascular pathophysiology is one of the most important pathophysiological components of TBI, but its role and molecular mechanisms remain largely unknown. This chapter reviews experimental studies of cerebrovascular pathophysiology, especially in rodent TBI models. Clinically translational advantages and limitations of each commonly used rodent TBI models in the study of vascular responses are also discussed.