Abstract
A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
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CITATION STYLE
Blacksell, S. D., Tanganuchitcharnchai, A., Jarman, R. G., Gibbons, R. V., Paris, D. H., Bailey, M. S., … De Silva, H. J. (2011). Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection. Clinical and Vaccine Immunology, 18(10), 1773–1775. https://doi.org/10.1128/CVI.05288-11
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