In vitro susceptibility to closthioamide among clinical and reference strains of Neisseria gonorrhoeae

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Abstract

Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae.

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Miari, V. F., Solanki, P., Hleba, Y., Stabler, R. A., & Heap, J. T. (2017). In vitro susceptibility to closthioamide among clinical and reference strains of Neisseria gonorrhoeae. Antimicrobial Agents and Chemotherapy, 61(10). https://doi.org/10.1128/AAC.00929-17

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