Geometric effects on complex network structure in the cortex

Abstract

It is shown that homogeneous, short-range, two-dimensional (2D) cortical connectivity, without modularity, hierarchy, or other specialized structure, reproduces key observed properties of cortical networks, including low path length, high clustering and modularity index, and apparent hierarchical block-diagonal structure in connection matrices. Geometry strongly influences connection matrices, implying that simple interpretations of connectivity measures as reflecting specialized structure can be misleading: Such apparent structure is seen in strictly uniform, locally connected architectures in 2D. Geometry is thus a proxy for function, modularity, and hierarchy and must be accounted for when structural inferences are made. © 2011 American Physical Society.