Targeting aging pathways in chronic obstructive pulmonary disease

62Citations
Citations of this article
117Readers
Mendeley users who have this article in their library.

Abstract

Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in lung function. Major risk factors for COPD are cigarette smoking and aging. COPD-associated pathomechanisms include multiple aging pathways such as telomere attrition, epigenetic alterations, altered nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell exhaustion and chronic inflammation. In this review, we will highlight the current literature that focuses on the role of age and aging-associated signaling pathways as well as their impact on current treatment strategies in the pathogenesis of COPD. Furthermore, we will discuss established and experimental COPD treatments including senolytic and anti-aging therapies and their potential use as novel treatment strategies in COPD.

Cite

CITATION STYLE

APA

Easter, M., Bollenbecker, S., Barnes, J. W., & Krick, S. (2020, September 2). Targeting aging pathways in chronic obstructive pulmonary disease. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms21186924

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free