Bioinformatics Challenges in the Proteomic Analysis of Human Plasma

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Abstract

Mass spectrometry has become the method of choice for studying proteins in complex mixtures in a qualitative and quantitative fashion. The application of mass spectrometry-based proteomics analyses on plasma has correspondingly been established as an important method for disease-associated biomarker discovery and validation. Yet despite being a readily available human sample, plasma poses several important challenges to the proteomics researcher. With a focus on bioinformatics aspects, this chapter will discuss the problems involved in analyzing plasma proteomics data, along with the scope of solutions available through specialised tools and sophisticated analysis methods.

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Foster, J. M., & Martens, L. (2011). Bioinformatics Challenges in the Proteomic Analysis of Human Plasma. In Methods in Molecular Biology (Vol. 728, pp. 333–347). Humana Press Inc. https://doi.org/10.1007/978-1-61779-068-3_22

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