Small activating RNAs (saRNAs) are a class of artificially designed short duplex RNAs targeted at the promoter of a particular gene to upregulate its expression via a mechanism known as RNA activation (RNAa) and hold great promise for treating a wide variety of diseases including those undruggable by conventional therapies. The therapeutic benefits of saRNAs have been demonstrated in a number of preclinical studies carried out in different disease models including cancer. With many tumor suppressor genes (TSGs) downregulated due to either epigenetic mechanisms or haploinsufficiency resulting from deletion/mutation, cancer is an ideal disease space for saRNA therapeutics which can restore the expression of TSGs via epigenetic reprogramming. The p21 WAF1/CIP gene is a TSG frequently downregulated in cancer and an saRNA for p21 WAF1/CIP known as dsP21-322 has been identified to be a sequence-specific p21 WAF1/CIP activator in a number of cancer types. In this chapter, we review preclinical development of medicinal dsP21-322 for cancer, especially prostate cancer and bladder cancer, and highlight its potential for further clinical development.
CITATION STYLE
Kang, M. R., Li, G., Pan, T., Xing, J. C., & Li, L. C. (2017). Development of therapeutic dsP21-322 for cancer treatment. In Advances in Experimental Medicine and Biology (Vol. 983, pp. 217–229). Springer New York LLC. https://doi.org/10.1007/978-981-10-4310-9_16
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