Ethical considerations in performing clinical trials in and for older people

Abstract

In Europe, the population is ageing rapidly. Older people are taking many medicinal products daily, and these may not necessarily be suitable for them. According to research studies, older patients are underrepresented in clinical trials, especially those who are over 75 years and have co-morbidities, concomitant treatments, and/or are frail. This document provides a summary of recommendations on ethical aspects of clinical trials with older people, who may in some cases be considered a vulnerable patient population. The EFGCP’s Geriatric Working Party (GMWP) has developed a guidance to promote such research and to support health care professionals in their efforts.