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This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting. To investigate potential sources of heterogeneity of the accuracy of the four-symptom screen between studies including: ART status, CD4 cell count, gestational age, pregnancy stage (pregnancy vs. postpartum), screening test definition of cough (any cough vs. cough greater than 2 weeks). To describe the accuracy of single symptoms included within the four-symptom screen, additional symptoms or symptom combinations, for identifying active TB in pregnant PLHIV. For example, additional symptoms may include failure to gain weight or fatigue.
Lacourse, S. M., Cranmer, L. M., Bekker, A., Steingart, K. R., Black, D., Horne, D. J., … Mathad, J. (2018). Symptom screening for active tuberculosis in pregnant women living with HIV. Cochrane Database of Systematic Reviews, 2018(1). https://doi.org/10.1002/14651858.CD012934