Enantioselective cyanation of benzaldehyde: An asymmetric polymeric catalyst in a microreactor

Abstract

A chiral salen ligand containing a carboxylic acid group was attached to macroporous monosized polystyrene-divinylbenzene beads grafted with (4-hydroxybutyl)vinyl ether groups. A Ti(IV) complex of the beads was used for enantioselective cyanations of benzaldehyde using trimethylsilyl cyanide and acetyl cyanide as cyanide sources using both conventional batch techniques and a microreactor. ©ARKAT-USA, Inc.