Catalytic Hydrodifluoroalkylation of Unactivated Olefins

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Abstract

Herein, we report a modular catalytic technique that streamlines the preparation of gem-difluoroalkanes from unactivated sp3 precursors. The method is characterized by its simplicity, generality, and site selectivity, including the functionalization of advanced intermediates and olefin feedstocks. Our approach is enabled by a cooperative interplay of halogen- and hydrogen-atom transfer, thus offering a new entry point to difluorinated alkyl bioisosteres of interest in drug discovery.

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Yue, W. J., Day, C. S., Brenes Rucinski, A. J., & Martin, R. (2022). Catalytic Hydrodifluoroalkylation of Unactivated Olefins. Organic Letters, 24(28), 5109–5114. https://doi.org/10.1021/acs.orglett.2c01941

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