Reliable detection of cis-regulatory elements in promoter regions is a difficult and unsolved problem in computational biology. The intricacy of transcriptional regulation in higher eukaryotes, primarily in metazoans, could be a major driving force of organismal complexity. Eukaryotic genome annotations have improved greatly due to large-scale characterization of full-length cDNAs, transcriptional start sites (TSSs), and comparative genomics. Regulatory elements are identified in promoter regions using a variety of enumerative or alignment-based methods. Here we present a survey of recent computational methods for eukaryotic promoter analysis and describe the use of an alignment-based method implemented in the A-GLAM program. © 2009 Humana Press, a part of Springer Science+Business Media, LLC.
CITATION STYLE
Mariño-Ramírez, L., Tharakaraman, K., Spouge, J. L., & Landsman, D. (2009). Promoter analysis: Gene regulatory motif identification with A-GLAM. Methods in Molecular Biology, 537, 263–276. https://doi.org/10.1007/978-1-59745-251-9_13
Mendeley helps you to discover research relevant for your work.