Percutaneous coronary interventions (PCI) are the mainstay for treatment of advanced coronary disease. A majority of PCI involve deployment of a stent in the affected vascular segment. This chapter introduces the concept of using stents as a platform for delivering gene therapies to the vasculature with the overarching aim of mitigating in-stent restenosis (ISR), late stent thrombosis (LST), and neoatherosclerosis (NA), a triad of delayed complications that reduce the overall success rate of PCI. The chapter provides a detailed methodology for coatless reversible attachment of adenoviral (Ad) and adeno-associated viral (AAV) vectors to the metal stent struts along with representative in vitro and in vivo results.
CITATION STYLE
Alferiev, I. S., Chorny, M., Wilensky, R. L., Levy, R. J., & Fishbein, I. (2022). Stent-Based Gene Delivery for Coronary Disease. In Methods in Molecular Biology (Vol. 2573, pp. 217–233). Humana Press Inc. https://doi.org/10.1007/978-1-0716-2707-5_17
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