Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

Abstract

We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2. Copyright © 2013, American Society for Microbiology. All Rights Reserved.