Efek Skopoletin dari Ekstrak Buah Mengkudu (Morinda Citrifolia) sebagai Modalitas Herbal dalam Penanganan Preeklamsia

Abstract

ABSTRACT Introduction: Preeclampsia is a disorder which usually occurs in normotensive women and characterized by hypertension. Preeclampsia often causes morbidity and mortality in both mother and fetus. Lots of deaths have been caused by preeclampsia every year. Thus, good and proper treatment need to be done. The aim of this writing is to find out and make a literature review about preeclampsia’s herbal-based treatment which is safe for pregnant women. Discussion: Many factors take part in the pathogenesis of preeclampsia, including increased oxidative stress and decreased nitric oxide (NO). Increased oxidative stress can cause placental dysfunction which will cause clinical manifestations of preeclampsia. Decreased NO can also cause clinical manifestations of preeclampsia. Scopoletin antioxidant from Morinda citrifolia fruit extract is able to prevent cell damage caused by oxidative stress and prevent inactivation of NO due to free radicals. Scopoletin was proven to significantly decrease blood pressure in rats with oxidative stress-related hypertension (PNL) and to significantly increase NO in the PNL group and the general hypertension group (PN). Conclusion: Treatment of preeclampsia can be done by scopoletin antioxidant, resulting in the effect on systolic and diastolic blood pressure and mean arterial pressure. Scopoletin also increases NO, resulting in a vasodilation effect. This writing is expected to be a help in advancing the treatment of preeclampsia in the future. Keywords: Morinda citrifolia, preeclampsia, scopoletin