Radiation-Induced Lung and Heart Toxicity

Abstract

For many patients with lung cancer, thoracic radiation therapy (TRT) is an integral part of their treatment. The effect of TRT on normal structures is an important consideration when optimizing treatment plans for patients. This chapter will review radiation therapy (RT)-induced lung and heart injury including both the clinical and biological mechanisms for these toxicities. It will also analyze the variety of predictors of RT-induced lung and heart damage as well as methods to prevent and treat these toxicities.