Meta-Analysis, Review and Update of Methodologies

Abstract

A meta-analysis is a systematic review with pooled outcome data. The current chapter gives a summary of methods for the purpose. Four scientific rules and three pitfalls are reviewed. The main benefit of meta-analysis is that it provides a pooled outcome with increased precision. The main criticisms are that so far they were not good at predicting subsequent large trials, and at predicting serious adverse effects of medicines.