Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the Hippocampus

274Citations
Citations of this article
332Readers
Mendeley users who have this article in their library.

Abstract

Long-term potentiation (LTP) is widely regarded as a memory mechanism, but it is not known whether it can last long enough to underlie very long-term memory. We report that high-frequency stimulation (HFS) paradigms applied to the rat dentate gyrus can elicit stable LTP lasting months and up to at least 1 year. The induction of stable LTP was sensitive to stimulation variables on the day of HFS and was associated with phosphorylation of cAMP response element-binding protein. The maintenance of stable LTP was also experience-dependent, because it was reversed when animals were exposed repeatedly to an enriched environment beginning 14 d post-HFS. However, stable LTP eventually consolidated over time and became resistant to reversal, because exposure to enriched environments 90 d post-HFS failed to influence stable LTP maintenance. Thus, LTP can be shown to meet one of the principal criteria for a very long-term memory storage mechanism. However, under naturalistic environmental conditions, LTP may normally be retained in the hippocampus for only short periods of time.

Cite

CITATION STYLE

APA

Abraham, W. C., Logan, B., Greenwood, J. M., & Dragunow, M. (2002). Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the Hippocampus. Journal of Neuroscience, 22(21), 9626–9634. https://doi.org/10.1523/jneurosci.22-21-09626.2002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free