Objective: Cordyceps sinensis (CS) is a popular natural Chinese herbal medicine for invigor-ation, health preservation and reducing fatigue. Its natural substance has been prepared as a fermentation product of a specific strain of Cordyceps sinensis (Cs-4). Our objective was to assess the effect of Cs-4 on the exercise capacity of the healthy elderly people in a randomized, double-blind, placebo-controlled trial. Methods: Thirty-seven healthy, elderly Chinese subjects were randomly assigned to receive either Cs-4 (3 g/ day) or identical placebo capsules. Their exercise performance was tested before and after 6 weeks of treatment with a symptom-limited, incremental work rate protocol on a cycle ergometer. Maximum oxygen uptake (VO2max) was measured using a metabolic chart. Anaerobic thresholds (VOz0) were identified by two observers using plots of both VCO2 vs VO2 and VE/VOz vs time. Results: After taking Cs-4 for 6 weeks, VOzmax (1.88-t-0.13 to 2.00_+0.14 L/min; P=0.050) and VO2O (1.15-t-0.07 to 1.30-+-0.09 L/min; P = O. 012) were significantly increased, whereas after placebo application they were unchanged. Conclusion: These findings support the belief held in China that Cs-4 could improve oxygen uptake or aerobic capacity and ventilation function and resistance to fatigue of elderly people in exercise.
CITATION STYLE
Yi, X., Xi-zhen, H., & Jia-shi, Z. (2004). Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs-4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Chinese Journal of Integrative Medicine, 10(3), 187–192. https://doi.org/10.1007/bf02836405
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