The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams

Abstract

Intraperitoneal vaccination of female mice, before mating, with a whole cell, heat-killed (62 °C) vaccine of Campylobacter jejuni allowed the mother to confer immunity to her young, challenged orally 4–6 days after birth with the homologous strain. There was no protection against a strain of another serotype. Heating the vaccine to 100 °C destroyed its protective properties. A vaccine prepared from an anagellate variant of the original strain was as protective as the original vaccine against challenge with the flagellated strain. Anti-flagellar serum antibody titres of the dams did not correlate with protection of their young. © 1986, Cambridge University Press. All rights reserved.