Murine models of polycystic kidney disease

27Citations
Citations of this article
52Readers
Mendeley users who have this article in their library.

Abstract

The current knowledge of human polycystic kidney disease (PKD) - its morphology as well as the current biochemical and molecular understanding of the disease - has been enormously aided by the existence of a variety of animal models. In mice, several spontaneous mutations have been identified that give rise to PKD. Furthermore, it has been possible to create experimental models of renal cystic disease by genetic manipulation. All these different models have been very informative in studying the role of growth hormones, cell differentiation and hyperplasia, ionic transport, oncogene expression and changes in extracellular matrix (ECM) composition during the development of PKD. Furthermore, they have allowed investigators to test different therapeutic approaches in vivo. This article will review the characteristics of the most common murine models of PKD, some of their current uses and the future role of these animal models in the understanding of human renal cystic disease.

Cite

CITATION STYLE

APA

Schieren, G., Pey, R., Bach, J., Hafner, M., & Gretz, N. (1996). Murine models of polycystic kidney disease. In Nephrology Dialysis Transplantation (Vol. 11, pp. 38–45). Oxford University Press. https://doi.org/10.1093/ndt/11.supp6.38

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free