Membranoproliferative glomerulonephritis

Abstract

MPGN is characterized by its peculiar histological findings; lobular appearance, cellular and mesangial matrix proliferation and double contoured capillary loops. Based on histomorphalogical pattern, three types are subdivided. MPGN may be primary (in most children) or secondary (in most adults) to chronic infections, cryoglobulinemia or systemic autoimmune disorders. Clinical manifestation of typical MPGN is nephrotic range proteinuria associated with microscopic hematuria, showing slowly progressive course. Treatment strategy is composed of exclusion of pathogen, especially in HCV positive MPGN, and intervention to autoimmune mechanism such as alternative-day steroid regimen.