Innovative biosensor of circulating breast cancer cells; a potential tool in latin america oncology rooms

Abstract

The detection of circulating tumoral cells represents the possibility for therapy monitoring as well as prevent metastasis in oncology patients. Portable and economical technologies are required in most of the oncology rooms of third level Latin America hospitals. In this work an innovative biosensor of circulating breast cancer cells on the basis of bioimpedance spectroscopy measurements assisted with magnetic nanoparticles is presented. The technical proposal involves a microfluidic system for cancer cells separation by immunomagnetic technique and its detection by multifrequency bioimpedance measurements. An experimental proof of concept to detect a typical breast cancer cell line was developed to evaluate the sensitivity of the system. The results shown the technical proposal feasibility as portable, inexpensive and non-invasive biosensor of circulating tumoral cells, as well as its technical feasibility for implementation in oncology rooms of Latin America third level hospitals.