Cisplatin is one of the most used drugs in the therapy of different types of cancer. However, its use is limited by nephrotoxicity. This study investigated the effects of a commercially available grape pomace extract (GE) from Vitis vinifera on cisplatin-induced kidney toxicity in rats. Sixty-four male Wistar albino rats were randomly divided into eight groups. Groups 1–3 were controls, receiving 0.9% saline and doses 1 and 2 of GE respectively. Cisplatin was given to groups 4–8. Two groups received pretreatment with GE, while another two groups received pre- and post-treatment with GE. Blood sampleswere collectedandall animals sacrificed. Kidneyswere harvestedfor histopathological analysis. GE significantly increased blood creatinine and urea levels, the severity of kidney histopathological damage, andmortality in all cisplatin groups, except for group 7which received pre- and post-treatment with a low dose of GE. Renal toxicity was determined by mortality and severe histopathological renal lesions. Additionally, the serum total antioxidant capacity (TAC) was not significantly modified in the treated groups compared to the control. These results indicate that the GE did not have a protective effect on cisplatin-induced nephrotoxicity; on the contrary, GE accentuated the toxic effect of cisplatin.
CITATION STYLE
Mitre, C. I., Neag, M. A., Mitre, A. O., Morhan, V., Catinean, A., Botan, E. C., … Buzoianu, A. D. (2019). Paradoxical effect of grape pomace extract on cisplatin-induced acute kidney injury in rats. Pharmaceutics, 11(12). https://doi.org/10.3390/pharmaceutics11120656
Mendeley helps you to discover research relevant for your work.