Clinical manifestations and MRI features of Danon disease: a case series

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Abstract

Background: Danon disease (DD) is an exceptionally uncommon X-linked dominant lysosomal glycogen storage disorder characterized by pronounced ventricular hypertrophy and cardiac insufficiency. The timely identification of cardiac impairment in individuals with DD holds significant clinical importance. Case presentation: We present a case of Danon Disease in a three-generation pedigree from Anhui Province, China. Clinical features and laboratory data were collected and analyzed for a 16-year-old male proband (III-1) and two affected female family members (II-2 and II-3). The proband exhibited Wolf-Parkinson-White syndrome, hypertrophic cardiomyopathy, abnormal cognitive function, and muscle weakness. Gene sequencing confirmed a mutation (c.963G > A) in the LAMP-2 gene. Conclusion: Patients with DD may present both dilated and hypertrophic cardiomyopathy. Comprehensive myocardial tissue characterization by MRI plays a key role in the diagnosis of the disease.

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Zhang, Y., Zhao, R., Yuan, Y., Yu, Y., Liu, B., & Li, X. (2023). Clinical manifestations and MRI features of Danon disease: a case series. BMC Cardiovascular Disorders, 23(1). https://doi.org/10.1186/s12872-023-03356-y

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