Abstract
Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Members of the neurotrophin family initiate downstream signaling via two types of neurotrophin receptors: Trks (TrkA, TrkB, and TrkC) and p75. This chapter reviews what is known about the structures and functions of Trk and p75: from ligand specificity and binding, initiation and regulation of intracellular signaling cascades, and crosstalks with other signaling pathways to the biological responses in the nervous system.
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CITATION STYLE
Pong Ng, Y., Yip Lo, K., Cheung, Z. H., & Ip, N. Y. (2006). Signaling Through the Neurotrophin Receptors. In Handbook of Neurochemistry and Molecular Neurobiology (pp. 11–41). Springer US. https://doi.org/10.1007/978-0-387-30381-9_2
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