Anisodamine, an antagonist of muscarinic receptor, has been used therapeutically to improve blood flow in circulatory disorders such as septic shock in China since 1965. The main mechanism of anisodamine for anti-shock proposed in Pharmacology for Chinese medical students is to improve blood flow in the microcirculation. Here, we suggest a new mechanism for its anti-shock effect. That is, anisodamine, by blocking muscarinic receptor, results in rerouting of acetylcholine to α7 nicotinic acetylcholine receptor (α7nAChR) bringing about increased acetylcholine-mediated activation of α7nAChR and the cholinergic anti-inflammatory pathway. © 2011 Zhao, Li, Liu, Su and Shen.
CITATION STYLE
Zhao, T., Li, D. J., Liu, C., Su, D. F., & Shen, F. M. (2011). Beneficial effects of anisodamine in shock involved cholinergic anti-inflammatory pathway. Frontiers in Pharmacology, MAY. https://doi.org/10.3389/fphar.2011.00023
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