Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone

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Abstract

In the postnatal forebrain, the subventricular zone (SVZ) contains a pool of undifferentiated cells, which proliferate and migrate along the rostral migratory stream (RMS) to the olfactory bulb and differentiate into granule cells and periglomerular cells. Plexin-B2 is a semaphorin receptor previously known to act on neuronal proliferation in the embryonic brain and neuronal migration in the cerebellum. We show here that, in the postnatal and adult CNS, Plexin-B2 is expressed in the subventricular zone lining the telencephalic ventricles and in the rostral migratory stream. We analyzed Plxnb2-/- mice and found that there is a marked reduction in the proliferation of SVZ cells in the mutant. Plexin-B2 expression is downregulated in the olfactory bulb as interneurons initiate radial migration. BrdU labeling and GFP electroporation into postnatal SVZ, in addition to time-lapse videomicroscopy, revealed that neuroblasts deficient for Plexin-B2 migrate faster than control ones and leave the RMS more rapidly. Overall, these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of SVZ-derived neuroblasts. © 2012 the authors.

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Saha, B., Ypsilanti, A. R., Boutin, C., Cremer, H., & Chédotal, A. (2012). Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone. Journal of Neuroscience, 32(47), 16892–16905. https://doi.org/10.1523/JNEUROSCI.0344-12.2012

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