The mniopetals, new inhibitors of reverse transcriptases from a mniopetalum species (basidiomycetes). I. Producing organism, fermentation, isolation and biological activities

Abstract

Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human immunodeficiency-, avian myeloblastosis and murine leukemia viruses were isolated from fermentations of a Canadian Mniopetalum species. They were named mniopetals A, B, C, D, E and F. Their structures were elucidated by spectroscopic methods. The compounds, in addition to their inhibitory activities on reverse transcriptases, exhibit antimicrobial and cytotoxic properties. © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.