Granilin — A new lactone from Inula grandis

Abstract

From the epigeal part of Inula grandis Schrenk., collected in the rosette-incipient stem formation period, a new sesquiterpene lactone has been isolated with the formula C15H20O4, mp 197–198°C, [α](Formula presented.)+147.9° (acetone), and we have called it granilin. On the basis of the NMR spectra of the initial substance and the products of its hydrogenation and acetylation, it has been established that granilin has the most probable structure of 1,3-dihydroxyeudesma-4(14), 11(13)-dien-7,8-olide. © 1974, Consultants Bureau. All rights reserved.