Rho proteins are master regulators of a large array of cellular functions, including control of cell morphology, cell migration and polarity, transcriptional activation, and cell cycle progression. They are the eukaryotic targets of various bacterial protein toxins and effectors, which activate or inactivate the GTPases. Here Rho-inactivating toxins and effectors are reviewed, including the families of large clostridial cytotoxins and C3-like transferases, which inactivate Rho GTPases by glucosylation and ADP-ribosylation, respectively. © Springer-Verlag 2005.
CITATION STYLE
Aktories, K., & Just, I. (2005). Clostridial Rho-inhibiting protein toxins. Current Topics in Microbiology and Immunology. Springer Verlag. https://doi.org/10.1007/3-540-27511-8_7
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