Steroid-resistant minimal change disease with ballooned podocytes

Abstract

Implication for health policy/practice/research/medical education: Minimal change disease (MCD) is a disorder affecting the kidneys which causes a nephrotic syndrome. The pathogenesis is unclear and genetic, immunological factors and infections have been studied as a possible trigger. We describe a case of steroid-resistent MCD with an unusual pattern of podocyte damage, occurred in children with coeliac disease, CMV infection and a variant in heterozygosis for the ACTN4 gene.