A physiological study of the effect of some food additives on the hypothalamic-pituitary-testis axis in male albino rats

Abstract

This research was conducted to know the effect of food additives Carmoisine, Monosodium Glutamate, and Sodium Benzoate on hypothalamic-pituitary-testis axis by measuring the level of some hormones (Luteinizing Hormone, Follicle Stimulating Hormone, Testosterone Hormone and Gonadotropin-Releasing Hormone) and biochemical parameters (Malondialdehyde, Superoxide dismutase, Catalase and glutathione). The current study included 32 male albino rats distributed in four groups, each group contains 8 animals, and the dose lasted for two months. The first group administered the dose of normal drinking water, the second group carmoisine at a concentration of 250 mg/kg of body weight, the third group-administered Monosodium Glutamate at a concentration of 15 mg/kg of body weight and the fourth group dosed the Sodium Benzoate at a concentration of 15 mg/kg of body weight. The results of the current study showed a significant decrease in the level of concentration of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Testosterone Hormone (T) and Gonadotropin. Releasing Hormone (GnRH) in animal serum for groups treated with food additives (T1, T2, T3) compared to the control group(C1). Results as well as was shown a significant increase in the level of Malondialdehyde and a significant decrease in the level of enzymatic and non-enzymatic antioxidants (Superoxide dismutase, Catalase and glutathione)in serum blood for group animals (T1, T2, T3) compared to control group (C1).