The role of cytotoxic T-lymphocyte associated antigen 4 (CTLA4) +49A/G and tumor necrosis factor alpha (TNF-α) -308G/A polymorphism in the development of celiac disease in Jordanian patients

Abstract

To test for the role of cytotoxic T-lymphocyte associated antigen 4 (CTLA4) +49A/G and tumor necrosis factor alpha (TNF-α) -308G/A polymorphisms in the development of celiac disease (CD) in Jordanian patients we investigated 85 patients, 30 CD families and 100 healthy matched controls. In this work we found that, the frequency of the CTLA4 +49GG genotype and G allele were significantly higher in patients when compared with controls. This significant increase in the frequency of both, GG genotype and G allele, is also demonstrated in CD families. No significant differences were found in TNF-α -308G/A polymorphisms in CD patients compared with control group. No significant differences in the frequency were found when the family group compared with the control group for both AA genotype and A allele. Our results demonstrated the importance of CTLA4 +49G allele in the development of CD among Jordanian CD patients and that no significant association of this disease with TNF-α -308A allele. ©2010 The Pharmaceutical Society of Japan.