Hepatocyte Growth Factor Level in Cerebrospinal Fluid as an Additional Marker in Patient with Drug-Resistant Streptococcus Pneumoniae Meningitis Treated with Linezolid

  • Tsai H
  • Chen Y
  • Lee S
  • et al.
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Abstract

Hepatocyte growth factor (HGF) is a multifunctional cytokine that has well-defined mitogenic, motogenic, and morphogenic functions on the epithelial cells. Strong increases of HGF concentrations in cerebrospinal fluid (CSF) are only present in patients with acute bacterial meningitis. We report a 15-year-old young man with drug resistant Streptococcus pneumoniae meningitis complicated with right 6th cranial nerve palsy. He presented with fever, headache and neck stiffness for 3 days and was treated with intravenous antimicrobial agents including linezolid and dexamethasone successfully. An association between CSF HGF concentrations and CSF proteins is observed (r = 0.897, p = 0.039. Pearson correlation test). This result showed that HGF level in CSF might act as an additional marker in patients with bacterial meningitis.

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Tsai, H.-C., Chen, Y.-S., Lee, S. S.-J., Lin, Y.-H., Wann, S.-R., Sy, C. L., & Liu, Y.-C. (2008). Hepatocyte Growth Factor Level in Cerebrospinal Fluid as an Additional Marker in Patient with Drug-Resistant Streptococcus Pneumoniae Meningitis Treated with Linezolid. Clinical Medicine: Case Reports, 1, CCRep.S759. https://doi.org/10.4137/ccrep.s759

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