Correlating histone modifi cation patterns with gene expression data during hematopoiesis

6Citations
Citations of this article
22Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Hematopoietic stem cells (HSC) in mammals are an ideal system to study differentiation. While transcription factors (TFs) control the differentiation of HSCs to distinctive terminal blood cells, accumulating evidence suggests that chromatin structure and modifications constitute another critical layer of gene regulation. Recent genome-wide studies based on next-generation sequencing reveal that histone modifications are linked to gene expression and contribute to hematopoiesis. Here, we briefly review the bioinformatics aspects for ChIP-Seq and RNA-Seq data analysis with applications to the epigenetic studies of hematopoiesis and provide a practical guide to several basic data analysis methods.

Cite

CITATION STYLE

APA

Hu, G., & Zhao, K. (2014). Correlating histone modifi cation patterns with gene expression data during hematopoiesis. Methods in Molecular Biology, 1150, 175–187. https://doi.org/10.1007/978-1-4939-0512-6_11

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free