Gene-Gene Interactions

Abstract

Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied. Different test statistics for the two-locus interaction model are discussed. Their relation to contrasting log-odds ratios and contrasting LD measures are given. Their relation to the log-linear model is also discussed. For higher order gene-gene interactions, the multifactor dimensionality reduction method and logic regression are briefly discussed.