There have been at least two major concerns with use of HBOCs as resuscitation fluids for traumatic hemorrhage: potential coagulopathy and interference with conventional clinical laboratory coagulation measurements.
CITATION STYLE
Jahr, J. S., Chung, M., Anvarhosseini, A., & Kim, H. W. (2013). Effects of hemoglobin-based oxygen carriers on blood coagulation. In Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics (Vol. 9783642407178, pp. 647–664). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-40717-8_34
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