The Role of RANK-Ligand Inhibition in Cancer: The Story of Denosumab

  • Castellano D
  • Sepulveda J
  • García-Escobar I
  • et al.
121Citations
Citations of this article
108Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The diagnosis of bone metastases is an event with certain consequences for the patient. They often mean pain and can also mean pathological fractures, hypercalcemia, and spinal cord compression, all synonymous with a diminished quality of life and often also hospitalization. Since the advent of the intravenous bisphosphonates, things began to look a bit brighter for patients with bone metastases—bone destruction was kept at bay a little longer. The next generation of bone metastasis treatments is well on its way in clinical development, and among them, the most advanced drug is denosumab. Denosumab is a fully human monoclonal antibody that inhibits osteoclast maturation, activation, and function by binding to receptor activator of nuclear factor kappa B ligand, with the final result being a reduced rate of bone resorption. In this review, we give an overview of relevant preclinical and clinical data regarding the use of denosumab in patients with solid tumors in general and prostate cancer in particular.

Cite

CITATION STYLE

APA

Castellano, D., Sepulveda, J. M., García-Escobar, I., Rodriguez-Antolín, A., Sundlöv, A., & Cortes-Funes, H. (2011). The Role of RANK-Ligand Inhibition in Cancer: The Story of Denosumab. The Oncologist, 16(2), 136–145. https://doi.org/10.1634/theoncologist.2010-0154

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free