Toll-Like Receptor-Mediated Endocytosis in Infectious Disease

Abstract

Toll-like receptors (TLR)Toll-like receptors (TLR) present a crucial first line of defense to attack by pathogens. In addition, the diversity and widespread localization of TLRs in the human body make them prime candidates for the development of therapeutics. TLRs are known to function by inducing the release of cytokines that result in an inflammation state. However, this release of cytokines needs to be tightly regulated in order to prevent adverse reactions such as sepsis. In this chapter, we describe the role of TLRs in pathogenesis and present various strategies that have been developed to target TLRs, including formulations and administration routes, with the help of various examples.