Superoxide dismutase and glutathione peroxidase in dogs with leishmaniasis following antimoniate therapy

Abstract

The effect of antimony treatment on antioxidative enzyme activities of erythrocyte superoxide dismutase (SOD) and blood glutathione peroxidase (GSHPx) and the associations between these enzyme activities and hematological indices of anemia (pre- and posttreatment) was studied in dogs with leishmaniasis. Twelve dogs with leishmaniasis before and after 60 days of therapy with N-methylglucamine antimoniate were used. No significant differences in antioxidant SOD and GSHPx activities or hematological indices, including HGB level, RBC number, HCT, MCV, MCH, and MCHC, were detected between pre- and post-antimony treatment. Results indicated that the presence or absence of previous treatment with antimony had no statistically identifiable effects on antioxidant enzyme activity or hematological indices.