Advances and problems of biospecific hemosorption

Abstract

Hemosorption over activated carbon is a recognized method of treatment of exo- and endogenous intoxications. However activated carbons are non-selective adsorbents and remove physiologically important metabolites along with toxins. Novel biospecific sorbents based on polyacrylamide with incorporated bioligands have been designed to eliminate target high molecular weight biotoxins. Biospecific adsorbents with immobilized ovomucoid (Ovosorb), L-tryptophan and Polymyxin E (Lyposorb) were produced. Hemosorption with biospecific sorbents significantly improved clinical results and conditions of patients with acute pancreatitis (Ovosorb), severe asthma (L-tryptophan) and abdominal sepsis (Lyposorb). © 2011 Springer Science+Business Media B.V.