As transcription factors that regulate expression of a variety of genes essential for diverse physiological and pathological processes, nuclear factor kappa B (NF-κB) family molecules play important roles in the development and progression of malignant tumor, and constitutive activation of NF-κB has been evidenced in various types of tumor tissues. Underlying its pathologic role, deregulated expression and/or transactivating activity of NF-κB usually involves multiple layers of molecular mechanisms. Noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are known to modulate expression and biological functions of regulatory proteins in a variety of cancer contexts. In this chapter, the regulatory role of miRNAs and lncRNAs in NF-κB signaling in malignant diseases will be discussed.
CITATION STYLE
Li, M., & Guan, H. (2016). Noncoding RNAs regulating NF-κB signaling. In Advances in Experimental Medicine and Biology (Vol. 927, pp. 317–336). Springer New York LLC. https://doi.org/10.1007/978-981-10-1498-7_12
Mendeley helps you to discover research relevant for your work.